Product

Details:​

A synthetic tripeptide corresponding to the C-terminal sequence (Lys-Pro-Val) of the naturally occurring neuroimmunomodulatory hormone alpha-melanocyte-stimulating hormone ($\alpha$-MSH). Despite lacking the melanotropic, skin-pigmenting properties of the full-length hormone, it retains and concentrates $\alpha$-MSH’s most potent anti-inflammatory, antimicrobial, and cytoprotective mechanisms. It functions intracellularly by translocating into the cell nucleus, directly inhibiting the translocation and activation of nuclear factor kappa B (NF-$\kappa$B), and suppressing systemic pro-inflammatory cytokine expression.

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Key Benefits:

• Potent NF-$\kappa$B Inhibition: Directly blocks the primary master switch of chronic inflammation (NF-$\kappa$B), drastically shutting down upstream production of pro-inflammatory cytokines such as IL-1$\beta$, IL-6, and TNF-$\alpha$.

• Gastrointestinal & Mucosal Healing: Exerts profound anti-colitic activity by soothing intestinal epithelial inflammation, restoring tight junction integrity, and accelerating mucosal recovery without immunosuppressive side effects.

• Broad-Spectrum Antimicrobial Defense: Possesses documented antimicrobial and antifungal properties, effectively disrupting pathogens such as Staphylococcus aureus and Candida albicans without disturbing beneficial microflora balance.

• Dermatological & Wound Modulation: Accelerates dermal healing, minimizes hypertrophic scar/keloid formation, and calms inflammatory skin disorders like eczema, psoriasis, and dermatitis.

• Absence of Pigmenting Side Effects: Operates independently of the melanocortin-1 receptor (MC1R) pathways that induce tanning or melanogenesis, allowing high-dose targeted therapeutic application without skin darkening.

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Ideal For:

• Individuals managing inflammatory bowel issues, including leaky gut, ulcerative colitis, Crohn's flares, SIBO, or chronic systemic gut permeability.

• Targeted inflammatory skin and mast cell protocols, such as stubborn dermatitis, rosacea, histamine intolerance, or MCAS-driven systemic flares.

• Autoimmune and chronic inflammatory states, offering deep, targeted anti-inflammatory signaling without the catabolic side effects or hormonal disruptions of corticosteroids.