Overview
A modified 16-amino acid fragment (amino acids 176-191) of the C-terminus of human growth hormone with an added tyrosine at the N-terminus. AOD-9604 retains the lipolytic activity of hGH without its growth-promoting or diabetogenic effects.
Mechanism of Action
It stimulates lipolysis and inhibits lipogenesis through a mechanism distinct from the GH receptor, acting on beta-3 adrenergic receptors in adipose tissue.
​Research Summary & Key Findings
Preclinical studies showed significant fat reduction without effects on IGF-1, glucose, or insulin levels. Phase 2b clinical trial showed modest but statistically significant weight reduction. TGA (Australia) approved as a food supplement. Limited Phase 3 clinical evidence.
Clinical Status
INVESTIGATIONAL
AOD-9604 is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
Subcutaneous injection (weekly)
Oral (daily - Rybelsus)
References
PRIMARY LITERATURE
PRIMARY LITERATUREPeer-reviewed literature indexed by the National Library of Medicine.
Registered interventional and observational studies, including status and phase.
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
Administration Routes
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AOD-9604
A modified 16-amino acid fragment (amino acids 176-191) of the C-terminus of human growth hormone with an added tyrosine at the N-terminus. AOD-9604…
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